Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells.

ABSTRACT: New approaches are being studied for the treatment of skin cancer. It has been reported that light combined with cisplatinum may be effective against skin cancer. In the present study, the effects of specific light radiations and cisplatinum on A431 cutaneous squamous cell carcinoma (cSCC) and HaCaT non‑tumorigenic cell lines were investigated. Both cell lines were exposed to blue and red light sources for 3 days prior to cisplatinum treatment. Viability, apoptosis, cell cycle progression and apoptotic‑related protein expression levels were investigated. The present results highlighted that combined treatment with blue light and cisplatinum was more effective in reducing cell viability compared with single treatments. Specifically, an increase in the apoptotic rate was observed when the ce

SUBMITTER: Tartaglione MF 

PROVIDER: S-EPMC7891828 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature