Independent reaction times method in Geant4-DNA: Implementation and performance.

ABSTRACT:

Purpose

The simulation of individual particle tracks and the chemical stage following water radiolysis in biological tissue is an effective means of improving our knowledge of the physico-chemical contribution to the biological effect of ionizing radiation. However, the step-by-step simulation of the reaction kinetics of radiolytic species is the most time-consuming task in Monte Carlo track-structure simulations, with long simulation times that are an impediment to research. In this work, we present the implementation of the independent reaction times (IRT) method in Geant4-DNA Monte Carlo toolkit to improve the computational efficiency of calculating G-values, defined as the number of chemical species created or lost per 100 eV of deposited energy.

Methods

The computationa

SUBMITTER: Ramos-Mendez J 

PROVIDER: S-EPMC7891885 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature