Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era.

ABSTRACT:

Background

The UK Severe Asthma Registry (UKSAR) is the world's largest national severe asthma registry collecting standardised data on referrals to UK specialist services. Novel biologic therapies have transformed the management of type 2(T2)-high severe asthma but have highlighted unmet need in patients with persisting symptoms despite suppression of T2-cytokine pathways with corticosteroids.

Methods

Demographic, clinical and treatments characteristics for patients meeting European Respiratory Society / American Thoracic Society severe asthma criteria were examined for 2225 patients attending 15 specialist severe asthma centres. We assessed differences in biomarker low patients (fractional exhaled nitric oxide (FeNO) <25 ppb, blood eosinophils <150/μL) compared with a biom

SUBMITTER: Jackson DJ 

PROVIDER: S-EPMC7892381 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature