JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara^®-Induced Skin Inflammation.

ABSTRACT: c-Jun N-terminal protein kinase 1 (JNK1) is involved in multiple biological processes but its implication in inflammatory skin diseases is still poorly defined. Herein, we studied the role of JNK1 in the context of Aldara^®-induced skin inflammation. We observed that constitutive ablation of JNK1 reduced Aldara^®-induced acanthosis and expression of inflammatory markers. Conditional deletion of JNK1 in myeloid cells led to reduced skin inflammation, a finding that was associated with impaired Aldara^®-induced inflammasome activation in vitro. Next, we evaluated the specific role of JNK1 in epidermal cells. We observed reduced Aldara^®-induced acanthosis despite similar levels of inflammatory markers. Transcriptomic and epigenomic analysis of k

SUBMITTER: Le A 

PROVIDER: S-EPMC7892463 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature