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A Review of Newly Diagnosed Glioblastoma.

ABSTRACT: Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomide maintenance. This review provides a summary of the epidemiological, clinical, histologic and genetic characteristics of newly diagnosed disease as well as the current standard of care and potential future therapeutic prospects.

SUBMITTER: Oronsky B 

PROVIDER: S-EPMC7892469 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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A Review of Newly Diagnosed Glioblastoma.

Oronsky Bryan B   Reid Tony R TR   Oronsky Arnold A   Sandhu Navjot N   Knox Susan J SJ  

Frontiers in oncology 20210205

Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomide maintenance. This review provides a summary of the epidemiological, clinical, histologic and genetic characteristics of newly diagnosed disease as well as the current standard of care and potential  ...[more]

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