Hierarchical modeling of mechano-chemical dynamics of epithelial sheets across cells and tissue.

ABSTRACT: Collective cell migration is a fundamental process in embryonic development and tissue homeostasis. This is a macroscopic population-level phenomenon that emerges across hierarchy from microscopic cell-cell interactions; however, the underlying mechanism remains unclear. Here, we addressed this issue by focusing on epithelial collective cell migration, driven by the mechanical force regulated by chemical signals of traveling ERK activation waves, observed in wound healing. We propose a hierarchical mathematical framework for understanding how cells are orchestrated through mechanochemical cell-cell interaction. In this framework, we mathematically transformed a particle-based model at the cellular level into a continuum model at the tissue level. The continuum model described relationships

SUBMITTER: Asakura Y 

PROVIDER: S-EPMC7892579 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature