Territory-Wide Chinese Cohort of Long QT Syndrome: Random Survival Forest and Cox Analyses.

ABSTRACT: Introduction: Congenital long QT syndrome (LQTS) is a cardiac ion channelopathy that predisposes affected individuals to spontaneous ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD). The main aims of the study were to: (1) provide a description of the local epidemiology of LQTS, (2) identify significant risk factors of ventricular arrhythmias in this cohort, and (3) compare the performance of traditional Cox regression with that of random survival forests. Methods: This was a territory-wide retrospective cohort study of patients diagnosed with congenital LQTS between 1997 and 2019. The primary outcome was spontaneous VT/VF. Results: This study included 121 patients [median age of initial presentation: 20 (interquartile range: 8-44) years, 62%

SUBMITTER: Tse G 

PROVIDER: S-EPMC7892622 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature