Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze.

ABSTRACT:

Background

Childhood asthma developmental programming is complex. Maternal asthma is a strong risk factor for childhood asthma, whereas vitamin D (VD) has emerged as a modifiable prenatal exposure.

Objective

Our aim was to examine the combined effect of early and late prenatal VD status in during pregnancies in women with and without asthma on childhood asthma or recurrent wheeze development.

Methods

We conducted a cohort study using prospectively collected data from the Vitamin D Antenatal Asthma Reduction Trial, a randomized, double-blinded, placebo-controlled VD supplementation trial in pregnant women at high risk of offspring asthma (N = 806 mother-offspring pairs). 25-Hydroxyvitamin-D (25(OH)D) level was measured in early and late pregnancy. Our main exposure was

SUBMITTER: Lu M 

PROVIDER: S-EPMC7892633 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature