The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity.

ABSTRACT: Flame retardant chemicals (FRCs) commonly added to many consumer products present a human exposure burden associated with adverse health effects. Under pressure from consumers, FRC manufacturers have adopted some purportedly safer replacements for first-generation brominated diphenyl ethers (BDEs). In contrast, second and third-generation organophosphates and other alternative chemistries have limited bioactivity data available to estimate their hazard potential. In order to evaluate the toxicity of existing and potential replacement FRCs, we need efficient screening methods. We built a 61-FRC library in which we systemically assessed developmental toxicity and potential neurotoxicity effects in the embryonic zebrafish model. Data were compared to publicly available data generated in a bat

SUBMITTER: Truong L 

PROVIDER: S-EPMC7892636 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature