Improved clinical outcomes after non-invasive oocyte selection and Day 3 eSET in ICSI patients.

ABSTRACT:

Background

Non-invasive oocyte quality scoring, based on cumulus gene expression analysis, in combination with morphology scoring, can increase the clinical pregnancy (CPR) and live birth rates (LBR) in Day 3 eSET (elective single embryo transfer) ICSI patients. This was first investigated in a pilot study and is now confirmed in a large patient cohort of 633 patients. It was investigated whether CPR, LBR and time-to-pregnancy could be improved by analyzing the gene expression profile of three predictive genes in the cumulus cells, compared to patients with morphology-based embryo selection only.

Methods

A large interventional, non-randomized, assessor-blinded cohort study with 633 ICSI patients was conducted in a tertiary fertility center. Non-PCOS patients, 22-39 years old

SUBMITTER: Van Vaerenbergh I 

PROVIDER: S-EPMC7892761 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature