Dysregulation of phospholipase and cyclooxygenase expression is involved in Schizophrenia.

ABSTRACT:

Background

Schizophrenia (SZ) is a severe mental disease with highly heterogeneous clinical manifestations and pathological mechanisms. Schizophrenia is linked to abnormalities in cell membrane phospholipids and blunting of the niacin skin flush response, but the associations between these phenotypes and its molecular pathogenesis remain unclear. This study aimed to describe the PLA2/COX pathway, the key link between phospholipids and niacin flush, and to illustrate the pathogenic mechanisms in schizophrenia that mediate the above phenotypes.

Methods

A total of 166 patients with schizophrenia and 54 healthy controls were recruited in this study and assigned to a discovery set and a validation set. We assessed the mRNA levels of 19 genes related to the PLA2/COX cascade in leu

SUBMITTER: Yang X 

PROVIDER: S-EPMC7892797 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature