Flexible brain dynamics underpins complex behaviours as observed in Parkinson's disease.

ABSTRACT: Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinson's disease (PD). To test this hypothesis, we studied the 'functional repertoire'-the number of distinct configurations of neural activity-using source-reconstructed magnetoencephalography in PD patients and controls. We found stereotyped brain dynamics and reduced flexibility in PD. The intensity of this reduction was proportional to symptoms severity, which can be explained by beta-band hyper-synchronization. Moreover, the basal ganglia were prominently involved in

SUBMITTER: Sorrentino P 

PROVIDER: S-EPMC7892831 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature