Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis.

ABSTRACT: Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity. We previously reported explorative multivariate analysis by hierarchical clustering of proteomics data of MS patients and controls, which resulted in two groups of individuals. Grouping reflected increased levels of intrathecal inflammatory response proteins and decreased levels of proteins involved in neural development in one group relative to the other group. MS patients and controls were present in both groups. Here we reanalysed these data and we also reanalysed data from an independent cohort of patients diagnosed with clinically isolated syndrome (CIS), who

SUBMITTER: Mosleth EF 

PROVIDER: S-EPMC7892850 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature