Identification and Validation of an Autophagy-Related lncRNA Signature for Patients With Breast Cancer.

ABSTRACT:

Background

Autophagy is a "self-feeding" phenomenon of cells, which is crucial in mammalian development. Long non-coding RNA (lncRNA) is a new regulatory factor for cell autophagy, which can regulate the process of autophagy to affect tumor progression. However, poor attention has been paid to the roles of autophagy-related lncRNAs in breast cancer.

Objective

This study aimed to construct an autophagy-related lncRNA signature that can effectively predict the prognosis of breast cancer patients and explore the potential functions of these lncRNAs.

Methods

The RNA sequencing (RNA-Seq) data of breast cancer patients was collected from The Cancer Genome Atlas (TCGA) database and the GSE20685 database. Multivariate Cox analysis was implemented to produce an autophagy-relat

SUBMITTER: Zhang R 

PROVIDER: S-EPMC7892971 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature