One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission.

ABSTRACT:

Objectives

Antibacterial resistance (ABR) is a major global health security threat, with a disproportionate burden on lower-and middle-income countries (LMICs). It is not understood how 'One Health', where human health is co-dependent on animal health and the environment, might impact the burden of ABR in LMICs. Thailand's 2017 "National Strategic Plan on Antimicrobial Resistance" (NSP-AMR) aims to reduce AMR morbidity by 50% through 20% reductions in human and 30% in animal antibacterial use (ABU). There is a need to understand the implications of such a plan within a One Health perspective.

Methods

A model of ABU, gut colonisation with extended-spectrum beta-lactamase (ESBL)-producing bacteria and transmission was calibrated using estimates of the prevalence of ESBL-produc

SUBMITTER: Booton RD 

PROVIDER: S-EPMC7892992 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature