Photoacoustic monitoring of oxygenation changes induced by therapeutic ultrasound in murine hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a highly vascular solid tumor. We have previously shown that ultrasound (US) therapy significantly reduces tumor vascularity. This study monitors US-induced changes in tumor oxygenation on murine HCC by photoacoustic imaging (PAI). Oxygen saturation and total hemoglobin were assessed by PAI before and after US treatments performed at different intensities of continuous wave (CW) bursts and pulsed wave (PW) bursts US. PAI revealed significant reduction both in HCC oxygen saturation and in total hemoglobin, proportional to the US intensity. Both CW bursts US (1.6 W/cm²) and the PW bursts US (0.8 W/cm²) significantly reduced HCC oxygen saturation and total hemoglobin which continued to diminish with time following the US treatment. The e

SUBMITTER: Karmacharya MB 

PROVIDER: S-EPMC7893035 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature