Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.

ABSTRACT:

Background and aims

Patients with cirrhosis and acute-on-chronic liver failure (ACLF) have immunosuppression, indicated by an increase in circulating immune-deficient monocytes. The aim of this study was to investigate simultaneously the major blood-immune cell subsets in these patients.

Material and methods

Blood taken from 67 patients with decompensated cirrhosis (including 35 critically ill with ACLF in the intensive care unit), and 12 healthy subjects, was assigned to either measurements of clinical blood counts and microarray (genomewide) analysis of RNA expression in whole-blood; microarray (genomewide) analysis of RNA expression in blood neutrophils; or assessment of neutrophil antimicrobial functions.

Results

Several features were found in patients with ACLF a

SUBMITTER: Weiss E 

PROVIDER: S-EPMC7893087 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature