Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy.

ABSTRACT: Progesterone is a steroid hormone that is critical for implantation and maintenance of pregnancy, and low levels are associated with higher miscarriage risk. However, little is known about its trajectory during early pregnancy. We sought to determine the gestational age-specific normative values of serum progesterone on a week-by-week basis, and its associated maternal and fetal factors, during the first trimester of a viable low-risk pregnancy. A cross-sectional study was conducted at KK Women's and Children's Hospital from 2013 to 2018. 590 women with a single viable intrauterine low-risk pregnancy, between gestational weeks 5 and 12, were recruited. Serum progesterone showed an increasing trend during the first trimester, with a transient decline between gestational weeks 6-8, correspon

SUBMITTER: Ku CW 

PROVIDER: S-EPMC7893162 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature