Effect of palmitoylation on the dimer formation of the human dopamine transporter.

ABSTRACT: The human dopamine transporter (hDAT) is one in three members of the monoamine transporter family (MAT). hDAT is essential for regulating the dopamine concentration in the synaptic cleft through dopamine reuptake into the presynaptic neuron; thereby controlling hDAT dopamine signaling. Dysfunction of the transporter is linked to several psychiatric disorders. hDAT and the other MATs have been shown to form oligomers in the plasma membrane, but only limited data exists on which dimeric and higher order oligomeric states are accessible and energetically favorable. In this work, we present several probable dimer conformations using computational coarse-grained self-assembly simulations and assess the relative stability of the different dimer conformations using umbrella sampling replica excha

SUBMITTER: Zeppelin T 

PROVIDER: S-EPMC7893171 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature