Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex.

ABSTRACT: Herpesviruses infect a majority of the human population, establishing lifelong latent infections for which there is no cure. Periodic viral reactivation spreads infection to new hosts while causing various disease states particularly detrimental in the immunocompromised. Efficient viral replication, and ultimately the spread of infection, is dependent on the nuclear egress complex (NEC), a conserved viral heterodimer that helps translocate viral capsids from the nucleus to the cytoplasm where they mature into infectious virions. Here, we have identified peptides, derived from the capsid protein UL25, that are capable of inhibiting the membrane-budding activity of the NEC from herpes simplex virus type 1 in vitro. We show that the inhibitory ability of the peptides depends on their length a

SUBMITTER: Draganova EB 

PROVIDER: S-EPMC7893173 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature