Sex Differences in Portopulmonary Hypertension.

ABSTRACT:

Background

Portopulmonary hypertension (POPH), pulmonary arterial hypertension that develops in the setting of portal hypertension, can lead to right-sided heart failure and death. Being female is a known risk factor for POPH, but little is known about the effect of sex on clinical manifestations, hemodynamics, treatment response, and survival.

Research question

We sought to characterize sex differences in clinical characteristics, pulmonary hemodynamics, treatment response, and survival in patients with POPH.

Study design and methods

We performed a retrospective cohort study of adult candidates for liver transplant (LT) who had POPH within the Organ Procurement and Transplantation Network database. Females and males were compared. Multivariate regression was performe

SUBMITTER: DuBrock HM 

PROVIDER: S-EPMC7893306 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature