Centromere protein U enhances the progression of bladder cancer by promoting mitochondrial ribosomal protein s28 expression.

ABSTRACT: Bladder cancer is one of the most common types of cancer. Most gene mutations related to bladder cancer are dominantly acquired gene mutations and are not inherited. Previous comparative transcriptome analysis of urinary bladder cancer and control samples has revealed a set of genes that may play a role in tumor progression. Here we set out to investigate further the expression of two candidate genes, centromere protein U (CENPU) and mitochondrial ribosomal protein s28 (MRPS28) to better understand their role in bladder cancer pathogenesis. Our results confirmed that CENPU is up-regulated in human bladder cancer tissues at mRNA and protein levels. Gain-of-function and loss-of-function studies in T24 human urinary bladder cancer cell line revealed a hierarchical relationship between CENPU a

SUBMITTER: Liu BB 

PROVIDER: S-EPMC7893492 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature