Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis.

ABSTRACT:

Background

Neuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results may be specific to the local sample investigated. Consequently, the findings reported in the existing literature are highly heterogeneous. This study aimed to overcome these issues by testing for neuroanatomical abnormalities in individuals with FEP that are expressed consistently across several independent samples.

Methods

Structural Magnetic Resonance Imaging data were acquired from a total of 572 FEP and 502 age and gender comparable healthy controls at five

SUBMITTER: Vieira S 

PROVIDER: S-EPMC7893510 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature