Effect of Tempol on the prevention of irradiation-induced mucositis in miniature pigs.

ABSTRACT:

Objective

The goals of this study were to (i) establish a useful miniature pig (minipig) model for irradiation-induced oral mucositis and (ii) evaluate the effect of Tempol to prevent its development.

Methods and materials

Minipigs were irradiated with 6 Gy for five consecutive days targeting the entire oral cavity. To prevent radiation damage, minipigs were treated with 30 mg kg^-1 Tempol 10 min before irradiation (n = 4), while the radiation-alone group was similarly injected with saline (n = 4). Lesions were graded using an oral mucositis score and visual inspection every 3 days, and biopsy of multiple sites was performed at day 18. Weight and chest and abdominal circumferences were measured every 3 days.

Results

Lesions began about 12 days after the firs

SUBMITTER: Hu L 

PROVIDER: S-EPMC7893613 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature