A systems-based method to repurpose marketed therapeutics for antiviral use: a SARS-CoV-2 case study.

ABSTRACT: This study describes two complementary methods that use network-based and sequence similarity tools to identify drug repurposing opportunities predicted to modulate viral proteins. This approach could be rapidly adapted to new and emerging viruses. The first method built and studied a virus-host-physical interaction network; a three-layer multimodal network of drug target proteins, human protein-protein interactions, and viral-host protein-protein interactions. The second method evaluated sequence similarity between viral proteins and other proteins, visualized by constructing a virus-host-similarity interaction network. Methods were validated on the human immunodeficiency virus, hepatitis B, hepatitis C, and human papillomavirus, then deployed on SARS-CoV-2. Comparison of virus-host-physi

SUBMITTER: Wang M 

PROVIDER: S-EPMC7893815 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature