Lower iodine storage in the placenta is associated with gestational diabetes mellitus.

ABSTRACT:

Background

The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects short-term iodine intake, to gestational diabetes mellitus (GDM) is inconclusive. Although the placental concentrations would better reflect the long-term gestational iodine status, no studies to date have investigated the association between the placental iodine load and the risk at GDM. Moreover, evidence is lacking whether placental iodine could play a role in biomarkers of insulin resistance and β-cell activity.

Methods

We assessed the incidence of GDM between weeks 24 and 28 of gestation for 471 mother-neonate pairs from the ENVIRONAGE birth cohort. In

SUBMITTER: Neven KY 

PROVIDER: S-EPMC7893873 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature