Inhibitory role of ATF3 in gastric cancer progression through regulating cell EMT and stemness.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common cancers and the third leading cause of cancer related mortality worldwide. The 5-year survival rate is rather low owing to advanced unresectable and distant metastasis. The EMT has been widely implicated in the stemness, metastatic dormancy, and chemoresistance of different solid tumors. Given the fact that activating transcription factor-3 (ATF3) is a member of the ATF/CREB family of transcription factors and its role in regulation of GC recurrence and metastasis remain poorly understood, the aim of the present study was to investigate its potential impact in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties and GC aggression.

Methods

To elucidate the potential role of ATF3 in gastric cance

SUBMITTER: Huang C 

PROVIDER: S-EPMC7893881 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature