Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis.

ABSTRACT:

Background

Sepsis is an emergency medical condition that can lead to death and it is defined as a life-threatening organ dysfunction caused by immune dysregulation in response to an infection. It is considered the main killer in intensive care units. Sepsis associated-encephalopathy (SAE) is mostly caused by a sepsis-induced systemic inflammatory response. Studies report SAE in 14-63% of septic patients. Main SAE symptoms are not specific and usually include acute impairment of consciousness, delirium and/or coma, along with electroencephalogram (EEG) changes. For those who recover from sepsis and SAE, impaired cognitive function, mobility and quality of life are often observed months to years after hospital discharge, and there is no treatment available today to prevent that. Infl

SUBMITTER: Di Bella D 

PROVIDER: S-EPMC7893894 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature