Regulatory T lymphocyte infiltration in metastatic breast cancer-an independent prognostic factor that changes with tumor progression.

ABSTRACT:

Background

Patients diagnosed with metastatic breast cancer have poor outcome with a median survival of approximately 2 years. While novel therapeutic options are urgently needed, the great majority of breast cancer research has focused on the primary tumor and less is known about metastatic breast cancer and the prognostic impact of the metastatic tumor microenvironment. Here we investigate the immune landscape in unique clinical material. We explore how the immune landscape changes with metastatic progression and elucidate the prognostic role of immune cells infiltrating primary tumors and corresponding lymph node and more importantly distant metastases.

Methods

Immunohistochemical staining was performed on human breast cancer tissue microarrays from primary tumors (n = 23

SUBMITTER: Stenstrom J 

PROVIDER: S-EPMC7893927 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature