The PD-L1 metabolic interactome intersects with choline metabolism and inflammation.

ABSTRACT:

Background

Harnessing the power of the immune system by using immune checkpoint inhibitors has resulted in some of the most exciting advances in cancer treatment. The full potential of this approach has, however, not been fully realized for treating many cancers such as pancreatic and breast cancer. Cancer metabolism influences many aspects of cancer progression including immune surveillance. An expanded understanding of how cancer metabolism can directly impact immune checkpoints may allow further optimization of immunotherapy. We therefore investigated, for the first time, the relationship between the overexpression of choline kinase-α (Chk-α), an enzyme observed in most cancers, and the expression of the immune checkpoint PD-L1.

Methods

We used small interfering RNA to do

SUBMITTER: Pacheco-Torres J 

PROVIDER: S-EPMC7893974 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature