Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets.

ABSTRACT:

Background

"Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., C-reactive protein, CRP) is high or low relative to its distribution. We have previously shown that the heritabilities (h ²) of coffee and alcohol consumption, postprandial lipemia, lipoproteins, leptin, adiponectin, adiposity, and pulmonary function are quantile-specific. Whether CRP heritability is quantile-specific is currently unknown.

Methods

Serum CRP concentrations from 2,036 sibships and 6,144 offspring-parent pairs were analyzed from the Framingham Heart Study. Quantile-specific heritability from full-sib (β_FS, h ² ={(1 + 8r_spouseβ_FS)^0.5 - 1}/(2r_spo

SUBMITTER: Williams PT 

PROVIDER: S-EPMC7894107 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature