Identification of a pre-possible multiple system atrophy phase.

ABSTRACT:

Objectives

A pre-possible multiple system atrophy (MSA) phase, that is, the period between symptom onset and satisfying the second consensus diagnostic criteria for possible or probable MSA, may exist. The aim of the study was to identify the pre-possible MSA phase and to pursue the earlier diagnosis of MSA.

Materials & methods

We reviewed 52 patients with a clinical diagnosis of MSA and 430 patients showing any signs of parkinsonism, sporadic cerebellar ataxia, or autonomic failure with other clinical diagnoses.

Results

The pre-possible MSA phase was noted in 35 patients with a clinical diagnosis of MSA and 13 patients with other clinical diagnoses. During this phase, 16 patients presented with autonomic features first, while they presented later in 32 patients. Betw

SUBMITTER: Osaki Y 

PROVIDER: S-EPMC7894314 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature