Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts.

ABSTRACT:

Background

Bisphenol S (BPS) is an endocrine-disrupting chemical and the second most abundant bisphenol detected in humans. In vivo BPS exposure leads to reduced binucleate cell number in the ovine placenta. Binucleate cells form by cellular fusion, similar to the human placental syncytiotrophoblast layer. Given that human placental syncytialization can be stimulated through epidermal growth factor (EGF), we hypothesized that BPS would reduce human cytotrophoblast syncytialization through disruption of EGF receptor (EGFR) signaling.

Objective

We tested whether BPS interferes EGFR signaling and disrupts human cytotrophoblast syncytialization.

Methods

We first tested BPS competition for EGFR using an EGF/EGFR AlphaLISA assay. Using human primary term cytotrophobl

SUBMITTER: Ticiani E 

PROVIDER: S-EPMC7894408 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature