Iron, coronary artery calcification, and mortality in patients undergoing hemodialysis.

ABSTRACT:

Objective

A high coronary artery calcification score (CACS) may be associated with high mortality in patients undergoing hemodialysis (HD). Recently, effects of iron on vascular smooth muscle cell calcification have been described. We aimed to investigate the relationships between iron, CACS, and mortality in HD patients.

Methods

We studied 173 consecutive patients who were undergoing maintenance HD. Laboratory data and Agatston's CACS were obtained at baseline for two groups of patients: those with CACS ≥400 (n = 109) and those with CACS <400 (n = 64). Logistic regression analyses for CACS ≥400 and Cox proportional hazard analyses for mortality were conducted.

Results

The median (interquartile range) age and duration of dialysis of the participants were

SUBMITTER: Mizuiri S 

PROVIDER: S-EPMC7894440 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature