Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks.

ABSTRACT: Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity. However, without tightly controlled immune responses, the host will be subjected to detrimental outcomes. Therefore, it is important to balance the positive and negative regulations of TLRs to eliminate pathogen infection, yet avert harmful immunological consequences. This study revealed a distinct mechanism underlying the regulation of the TLR network. The expression of sex-determining region Y-box 4 (Sox4) is induced by virus infection in viral infected patients and cultured cells, which subsequently represses the TLR signaling network to facilitate viral replication at multiple levels by a distinct mechan

SUBMITTER: Shang J 

PROVIDER: S-EPMC7894441 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature