Effectiveness of risk minimisation measures for valproate: A cross-sectional survey among physicians in Europe.

ABSTRACT:

Purpose

This study evaluated the effectiveness of risk minimisation measures (RMMs) implemented following the 2014 referral for valproate in Europe.

Methods

Cross-sectional survey was conducted over 2-month period in 2016 among physicians who prescribed valproate in France, Germany, the United Kingdom, Spain and Sweden. The web-based questionnaire included five endpoints to evaluate physicians' knowledge on (a) prescribing valproate only for epilepsy and bipolar disorder in women if other treatments were ineffective or not tolerated; (b) ensuring supervision by experienced physicians while treating these conditions; (c) considering alternative treatments for women planning pregnancy, regular review of treatment needs and re-assessing the benefit-risk balance in women and gir

SUBMITTER: Toussi M 

PROVIDER: S-EPMC7894483 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature