Regulation of plasma volume in male lowlanders during 4 days of exposure to hypobaric hypoxia equivalent to 3500 m altitude.

ABSTRACT:

Key points

Acclimatization to hypoxia leads to a reduction in plasma volume (PV) that restores arterial O₂ content. Findings from studies investigating the mechanisms underlying this PV contraction have been controversial, possibly as experimental conditions were inadequately controlled. We examined the mechanisms underlying the PV contraction evoked by 4 days of exposure to hypobaric hypoxia (HH) in 11 healthy lowlanders, while strictly controlling water intake, diet, temperature and physical activity. Exposure to HH-induced an ∼10% PV contraction that was accompanied by a reduction in total circulating protein mass, whereas diuretic fluid loss and total body water remained unchanged. Our data support an oncotically driven fluid redistribution from the intra- to the ext

SUBMITTER: Schlittler M 

PROVIDER: S-EPMC7894546 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature