Frequent platelet donation is associated with lymphopenia and risk of infections: A nationwide cohort study.

ABSTRACT:

Background

Recently, plateletpheresis donations using a widely used leukoreduction system (LRS) chamber have been associated with T-cell lymphopenia. However, clinical health consequences of plateletpheresis-associated lymphopenia are still unknown.

Study design and methods

A nationwide cohort study using the SCANDAT3-S database was conducted with all platelet- and plasmapheresis donors in Sweden between 1996 and 2017. A Cox proportional hazards model, using donations as time-dependent exposures, was used to assess the risk of infections associated with plateletpheresis donations using an LRS chamber.

Results

A total of 74 408 apheresis donors were included. Among donors with the same donation frequency, plateletpheresis donors using an LRS chamber were at an increase

SUBMITTER: Zhao J 

PROVIDER: S-EPMC7894559 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature