Cardiovascular risk factors and lifestyle behaviours in relation to longevity: a Mendelian randomization study.

ABSTRACT:

Background

The American Heart Association introduced the Life's Simple 7 initiative to improve cardiovascular health by modifying cardiovascular risk factors and lifestyle behaviours. It is unclear whether these risk factors are causally associated with longevity.

Objectives

This study aimed to investigate causal associations of Life's Simple 7 modifiable risk factors, as well as sleep and education, with longevity using the two-sample Mendelian randomization design.

Methods

Instrumental variables for the modifiable risk factors were obtained from large-scale genome-wide association studies. Data on longevity beyond the 90^th survival percentile were extracted from a genome-wide association meta-analysis with 11,262 cases and 25,483 controls whose age at dea

SUBMITTER: van Oort S 

PROVIDER: S-EPMC7894570 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature