Mitochondria Autoimmunity and MNRR1 in Breast Carcinogenesis: A Review.

ABSTRACT: We review here the evidence for participation of mitochondrial autoimmunity in BC inception and progression and propose a new paradigm that may challenge the prevailing thinking in oncogenesis by suggesting that mitochondrial autoimmunity is a major contributor to breast carcinogenesis and probably to the inception and progression of other solid tumors. It has been shown that MNRR1 mediated mitochondrial-nuclear function promotes BC cell growth and migration and the development of metastasis and constitutes a proof of concept supporting the participation of mitochondrial autoimmunity in breast carcinogenesis. The resemblance of the autoantibody profile in BC detected by IFA with that in the rheumatic autoimmune diseases suggested that studies on the autoantibody response to tumor associate

SUBMITTER: Madrid FF 

PROVIDER: S-EPMC7894625 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature