Characterizing tramadol users with potentially inappropriate co-medications: A latent class analysis among older adults.

ABSTRACT:

Background

Although tramadol is an effective weak opioid analgesic, careful monitoring of potential central nervous system adverse reactions in older adults is needed, especially when used with concomitant medications which may trigger the adverse effects. We aimed to characterize tramadol users with potentially inappropriate co-medications in older adults using a latent class analysis (LCA).

Method

Patients aged 65 years or older using tramadol and receiving potentially inappropriate co-medications were included from a nationwide healthcare claims database. We defined antidepressants, first-generation antihistamines, and anxiolytics as potentially inappropriate co-medications. We applied an LCA for grouping tramadol users based on the common characteristics of medication us

SUBMITTER: Yang BR 

PROVIDER: S-EPMC7894862 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature