Spatiotemporal relationship between subthreshold amyloid accumulation and aerobic glycolysis in the human brain.

ABSTRACT: In Alzheimer's disease, brain amyloid deposition has a distinct topography that correlates with aerobic glycolysis (AG), that is, the use of glucose beyond that predicted by oxygen consumption. The causes for this relationship remain unclear but might provide crucialinsight into how amyloid deposition begins. Here we develop methods to study the earliest topography of amyloid deposition based on amyloid imaging and investigate its spatiotemporal evolution with respect to the topography of AG in adults. We find that the spatiotemporal dynamics of amyloid deposition are largely explained by 1 factor, defined here as the amyloid topography dissimilarity index (ATDI). ATDI is bimodal, more highly dynamic during early amyloid accumulation, and predicts which individuals will cross a conservativ

SUBMITTER: Goyal MS 

PROVIDER: S-EPMC7894981 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature