Modeling regional changes in dynamic stability during sleep and wakefulness.

ABSTRACT: Global brain states are frequently placed within a unidimensional continuum by correlational studies, ranging from states of deep unconsciousness to ordinary wakefulness. An alternative is their multidimensional and mechanistic characterization in terms of different cognitive capacities, using computational models to reproduce the underlying neural dynamics. We explore this alternative by introducing a semi-empirical model linking regional activation and long-range functional connectivity in the different brain states visited during the natural wake-sleep cycle. Our model combines functional magnetic resonance imaging (fMRI) data, in vivo estimates of structural connectivity, and anatomically-informed priors to constrain the independent variation of regional activation. The best fit to emp

SUBMITTER: Ipina IP 

PROVIDER: S-EPMC7894985 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature