A durable protective immune response to wild-type measles virus infection of macaques is due to viral replication and spread in lymphoid tissues.

ABSTRACT: Infection with wild-type (WT) measles virus (MeV) is an important cause of childhood mortality that leads to lifelong protective immunity in survivors. WT MeV and the live-attenuated MeV used in the measles vaccine (LAMV) are antigenically similar, but the determinants of attenuation are unknown, and protective immunity induced by LAMV is less robust than that induced by WT MeV. To identify factors that contribute to these differences, we compared virologic and immunologic responses after respiratory infection of rhesus macaques with WT MeV or LAMV. In infected macaques, WT MeV replicated efficiently in B and T lymphocytes with spreading throughout lymphoid tissues resulting in prolonged persistence of viral RNA. In contrast, LAMV replicated efficiently in the respiratory tract but display

SUBMITTER: Lin WW 

PROVIDER: S-EPMC7895323 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature