Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial.

ABSTRACT:

Background

Increased intra-abdominal pressure causes hemodynamic changes that may affect renal biomarkers.

Methods

This randomized, single-blind, single-center clinical trial recruited patients undergoing laparoscopic cholecystectomy at a tertiary care center in Brazil. They were randomly allocated to a standard intra-abdominal pressure group (P10-12, 10-12 mm Hg) and a low intra-abdominal pressure group (P6-8, 6-8 mm Hg). The primary outcome was the change in neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels measured at the beginning of the procedure (T0), at the end of the procedure (T1), and 24 hours after the procedure (T2). P-values < 0.05 were considered statistically significant.

Results

In total, 64 patients completed the study-33 were gi

SUBMITTER: Marton Filho MA 

PROVIDER: S-EPMC7895340 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature