Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses.

ABSTRACT: Ionizing radiation-induced tissue damage recruits monocytes into the exposed area where they are differentiated to macrophages. These implement phagocytic removal of dying cells and elicit an acute inflammatory response, but can also facilitate tumorigenesis due to production of anti-inflammatory cytokines. Using primary human monocyte-derived macrophages (MDMs) and the THP1 monocytic cell line, we demonstrate that gamma radiation triggers monocyte differentiation toward the macrophage phenotype with increased expression of type I interferons (IFN-I) and both pro- and anti-inflammatory macrophage activation markers. We found that these changes correlate with significantly upregulated expression of 622 retroelements from various groups, particularly of several clades of human endogenous ret

SUBMITTER: Mikhalkevich N 

PROVIDER: S-EPMC7895352 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature