Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells.

ABSTRACT: During the development of a holometabolous insect such as Drosophila, specific group of cells in the larva survive during metamorphosis, unlike the other larval cells, and finally give rise to the differentiated adult structures. These cells, also known as Adult Progenitor Cells (APCs), maintain their multipotent capacity, differentially respond to hormonal and nutritional signals, survive the intrinsic and environmental stress and respond to the final differentiation cues. However, not much is known about the specific molecular mechanisms that account for their unique characteristics. Here we show that a specific Drosophila APC gene, headcase (hdc), has a dual role in the normal development of these cells. It acts at a systemic level by controlling the hormone ecdysone in the prothoracic

SUBMITTER: Giannios P 

PROVIDER: S-EPMC7895379 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature