Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.

ABSTRACT: The Hippo (Hpo) pathway regulates tissue growth in many animals. Multiple upstream components promote Hpo pathway activity, but the organization of these different inputs, the degree of crosstalk between them, and whether they are regulated in a distinct manner is not well understood. Kibra (Kib) activates the Hpo pathway by recruiting the core Hpo kinase cassette to the apical cortex. Here, we show that the Hpo pathway downregulates Drosophila Kib levels independently of Yorkie-mediated transcription. We find that Hpo signaling complex formation promotes Kib degradation via SCF^Slimb-mediated ubiquitination, that this effect requires Merlin, Salvador, Hpo, and Warts, and that this mechanism functions independently of other upstream Hpo pathway activators. Moreover, Kib de

SUBMITTER: Tokamov SA 

PROVIDER: S-EPMC7895526 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature