Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.

ABSTRACT:

Background

Fluid intelligence (FI) involves abstract problem-solving without prior knowledge. Greater age-related FI decline increases Alzheimer's disease (AD) risk, and recent studies suggest that certain dietary regimens may influence rates of decline. However, it is uncertain how long-term food consumption affects FI among adults with or without familial history of AD (FH) or APOE4 (ɛ4).

Objective

Observe how the total diet is associated with long-term cognition among mid- to late-life populations at-risk and not-at-risk for AD.

Methods

Among 1,787 mid-to-late-aged adult UK Biobank participants, 10-year FI trajectories were modeled and regressed onto the total diet based on self-reported intake of 49 whole foods from a Food Frequency Questionnaire (FFQ).

Results

SUBMITTER: Klinedinst BS 

PROVIDER: S-EPMC7895545 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature