Identification of a New Prognostic Risk Signature of Clear Cell Renal Cell Carcinoma Based on N⁶-Methyladenosine RNA Methylation Regulators.

ABSTRACT: As the most prevalent internal eukaryotic modification, N⁶-methyladenosine (m⁶A) is installed by methyltransferases, removed by demethylases, and recognized by readers. However, there are few studies on the role of m⁶A in clear cell renal cell carcinoma (ccRCC). In this study, we researched the RNA-seq transcriptome data of ccRCC in the TCGA dataset and used bioinformatics analyses to detect the relationship between m⁶A RNA methylation regulators and ccRCC. First, we compared the expression of 18 m⁶A RNA methylation regulators in ccRCC patients and normal tissues. Then, data from ccRCC patients were divided into two clusters by consensus clustering. LASSO Cox regression analysis was used to build a risk signature to predict the prognos

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7895564 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature